Much of our modern understanding and treatment of CAH comes from research conducted at Johns Hopkins Medical School in Baltimore in the middle of the 20th century. Lawson Wilkins , "founder" of pediatric endocrinology , worked out the apparently paradoxical pathophysiology: that hyperplasia and overproduction of adrenal androgens resulted from impaired capacity for making cortisol. He reported use of adrenal cortical extracts to treat children with CAH in 1950. Genital reconstructive surgery was also pioneered at Hopkins. After application of karyotyping to CAH and other intersex disorders in the 1950s, John Money , JL Hampson, and JG Hampson persuaded both the scientific community and the public that sex assignment should not be based on any single biological criterion, and gender identity was largely learned and has no simple relationship with chromosomes or hormones. See Intersex for a fuller history, including recent controversies over reconstructive surgery.
The human adrenal gland is composed of the cortex and the medulla. The medulla produces bioamines, and the adrenal cortex secretes several classes of steroids (corticosteroids). The adrenal cortex can be considered to be made up of three distinct subunits, each having a characteristic steroid profile. The outermost unit, the zona glomerulosa, produces mineralocorticoids, principally aldosterone (a salt-retaining hormone), which serve to maintain sodium and fluid balance. Glucocorticoids, primarily cortisol, arise from the central zona fasciculata and maintain glucose homeostasis and vascular integrity. The innermost subunit, the zona reticularis, secretes sex steroids (androgens). Disorders of adrenal steroidogenesis may involve overproduction, underproduction, or both the simultaneous overproduction and underproduction of corticosteroids ( Fig. 8-1 ). In this chapter, the following conditions are discussed:
Q. Had FMS for almost twenty years now, tried almost everything. Is Lyrica in the "steroid" family? Any one in this community could help me? I have given my few questions to find out an answer. I Had FMS for almost twenty years now, tried almost everything. I'm considering Lyrica but I'd like more info. Is Lyrica in the "steroid" family? If you go on Lyrica for a while & see no improvement with pain, is going off of it a big deal like with other med's, or can you simply just stop taking it? I take Ambien, will that have any interactions? I'm seeing my Doc about this at the end of the month, but I was hoping to get some personal experiences about it. Thanks for any thoughts! Thanks for your answers, keep them coming! A. according to this-
there is a moderate interaction. that means you can take them both but be checked regularly for depression of breath.