Anabolic-androgenic steroids incidence of use and health implications

Transdermal patches (adhesive patches placed on the skin) may also be used to deliver a steady dose through the skin and into the bloodstream. Testosterone-containing creams and gels that are applied daily to the skin are also available, but absorption is inefficient (roughly 10%, varying between individuals) and these treatments tend to be more expensive. Individuals who are especially physically active and/or bathe often may not be good candidates, since the medication can be washed off and may take up to six hours to be fully absorbed. There is also the risk that an intimate partner or child may come in contact with the application site and inadvertently dose himself or herself; children and women are highly sensitive to testosterone and can suffer unintended masculinization and health effects, even from small doses. Injection is the most common method used by individuals administering AAS for non-medical purposes. [45]

Anabolic androgenic steroids (AAS) were initially created for therapeutic purposes, and synthetic derivatives of the male hormone testosterone. Due its great anabolic effects, these drugs are being used on a large scale, for the improvement of sports performance. In this present study, we aim to show the history of it’ use, present their mechanisms of action, more particularly its use correlate with improved body composition, muscle mass, aerobic capacity and verify their possible side effects, analyzing their use therapeutic and indiscriminate, through direct scientific research with the sports. Sources were reviewed scientific the following search engines: PUBMED, LILACS and SCIELO. The results showed that in presence of a suitable AAS and diet can contribute to increases in body weight, particularly lean body mass and muscle strength gains achieved by high intensity exercise, these effects can be further potentiated, the use of supraphysiological doses, but in the aspect of aerobic power, there are not scientific evidence to support their improvement. Regarding side effects, the use of AAS, is related to several complications in the liver, cardiovascular system, reproductive system and psychological characteristics, always assigned by the non-therapeutic and abuse of AAS. Thus we conclude that the use of AAS, are directly linked to gains muscle mass, strength, as well several side effects, always assigned to abusive and indiscriminate doses, it is noteworthy that the scientific literature, still has a certain lack of studies, mainly randomized, controlled, with supraphysiological doses in human, so many effects are still unknown.

Androgens are responsible for the growth spurt of adolescence and for the eventual termination of linear growth which is brought about by the fusion of the epiphyseal growth centers. In children, exogenous androgens accelerate linear growth rates, but may cause a disproportionate advancement in bone maturation. Use over long periods may result in fusion of the epiphyseal growth centers and termination of growth process. Androgens have been reported to stimulate the production of red blood cells by enhancing the production of erythropoietic stimulating factor.

Millions of individuals have used illicit AAS, but because their use first appeared in the general population only in the 1980s, most people who use or used the drugs are still young or middle-aged. These data suggest that long-term illicit anabolic steroid use is associated with LV systolic and diastolic dysfunction, and (associated with lifetime duration of exposure) coronary atherosclerosis. Because a large majority of contemporary illicit anabolic steroid users are recreational weightlifters rather than competitive athletes, the possibility of illicit anabolic steroid use should be considered in young or middle-aged men with evidence of otherwise unexplained LV dysfunction or coronary artery disease.

Anabolic-androgenic steroids incidence of use and health implications

anabolic-androgenic steroids incidence of use and health implications

Millions of individuals have used illicit AAS, but because their use first appeared in the general population only in the 1980s, most people who use or used the drugs are still young or middle-aged. These data suggest that long-term illicit anabolic steroid use is associated with LV systolic and diastolic dysfunction, and (associated with lifetime duration of exposure) coronary atherosclerosis. Because a large majority of contemporary illicit anabolic steroid users are recreational weightlifters rather than competitive athletes, the possibility of illicit anabolic steroid use should be considered in young or middle-aged men with evidence of otherwise unexplained LV dysfunction or coronary artery disease.

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