If I ever forget to change one of me patches, that’s horrible. It’s the worst feeling ever forgetting to change a patch. Why’s that? Because it’s the same kind of medication what they give heroin addicts so it’s, if you forget to change it you get bad withdrawal symptoms so I’ll start itching all over, feeling hot and cold, headaches, unable to sleep and that’s just forgetting to change one day. So it’s horrible. Wow. What kind of patches are these, sorry, what’s the name of it? It’s buprenorphine. It’s like a morphine based. You mentioned the withdrawals there. You didn’t mention pain. Is pain something which gradually comes back as opposed to maybe in one day does the patch leave you in a lot of pain? No, if, well, really I don’t notice the pain if I’ve forgot to change the patch because the withdrawals are that bad, I just can’t think about anything to be honest and it’s sent me into hospital a couple of times where I’ve forgot to change it and I’ve had a bad reaction just from forgetting to change it for one day. When you were hospitalised, what were you suffering from then? At the same time, I’d just started a new medication because I’d reacted wrong, badly to that and because I’d forgot to change the patch, they both reacted badly together and it sent me kind of crazy and my friends started getting worried about me so mum took me into hospital and I ended up going three days without sleep. So they had to give me something to just knock me out of it. Okay. Do you mind just saying what you meant when you say you went a bit crazy? Well, I started I actually started hallucinating because I’d had an allergic reaction at the same time as withdrawal symptoms so I’d actually gone over to my friend’s house and I just asked her if I were a butterfly and it kind of freaked her out so that’s why they says, “We’d better get you to hospital.” Do you remember much about what happened? Yeah, I remember it all. It were, I’d started twitching really badly and the doctor at A and E could see that something were happening and that and at first they said, “Oh, you’ve got to try and get some sleep.” “Oh, I can’t. I’ve been trying for three days.” So then they gave me some diazepam to knock me out and then after I’d actually got some sleep, the patches eventually started kicking in and I started feeling better after a couple of days.
For many years, before modern methods had been developed, radical circumcision was the only treatment offered for tight foreskin. However, radical circumcision is now obsolete. It is more painful and has a more difficult recovery than the newer conservative treatments. Radical circumcision also destroys much functional tissue, results in severe loss of sexual sensation, and destroys normal male sexual-mechanical functioning. According to cost-benefit studies, radical circumcision is also the most expensive method of treating tight foreskin, but is still promoted by many medical doctors. Holman and Steussi provide us with an excellent description of this traditional but outmoded procedure. Choe and Kim provide a description and images of the traditional procedure.
In sexually mature male rabbits treated with finasteride at 543 times the human exposure (80 mg/kg/day) for up to 12 weeks, no effect on fertility, sperm count, or ejaculate volume was seen. In sexually mature male rats treated with 61 times the human exposure (80 mg/kg/day), there were no significant effects on fertility after 6 or 12 weeks of treatment; however, when treatment was continued for up to 24 or 30 weeks, there was an apparent decrease in fertility, fecundity and an associated significant decrease in the weights of the seminal vesicles and prostate. All these effects were reversible within 6 weeks of discontinuation of treatment. No drug-related effect on testes or on mating performance has been seen in rats or rabbits. This decrease in fertility in finasteride-treated rats is secondary to its effect on accessory sex organs (prostate and seminal vesicles) resulting in failure to form a seminal plug. The seminal plug is essential for normal fertility in rats and is not relevant in man.