Appropriate treatment with antibiotics can be very beneficial to Lyme disease pain. Additional medications used to manage the pain from chronic Lyme disease include non-steroidal anti-inflammatories, anticonvulsants, antidepressants, opioids, and muscle relaxants. Additional treatments include "restorative" yoga, enzymes, essential oils, prolotherapy, injections, relaxation, manual treatments and gentle exercises. Some patients use magnets, tens machines and creams. Oftentimes chiropractic (many types), physical therapy (multiple techniques) and acupuncture are extremely beneficial, although it can be trial and error to find the right practitioner who can be flexible to the variable needs of Lyme patients.
Glucocorticoids are potent anti-inflammatories, regardless of the inflammation's cause; their primary anti-inflammatory mechanism is lipocortin-1 (annexin-1) synthesis. Lipocortin-1 both suppresses phospholipase A2 , thereby blocking eicosanoid production, and inhibits various leukocyte inflammatory events ( epithelial adhesion , emigration , chemotaxis , phagocytosis , respiratory burst , etc.). In other words, glucocorticoids not only suppress immune response, but also inhibit the two main products of inflammation, prostaglandins and leukotrienes . They inhibit prostaglandin synthesis at the level of phospholipase A2 as well as at the level of cyclooxygenase /PGE isomerase (COX-1 and COX-2),  the latter effect being much like that of NSAIDs , potentiating the anti-inflammatory effect.