Many adverse effects of licorice poisoning can be seen and most are attributed to the mineralocorticoid effects of GZA. Depending on the dose and intake of licorice, serious problems and even hospitalization can arise. People with previously existing heart or kidney problems may be more susceptible to GZA and licorice poisoning.  It is important to monitor the amount of licorice consumed in order to prevent toxicity. It is difficult to determine a safe level, due to many varying factors from person to person. In the most sensitive individuals, daily intake of about 100 mg GZA can cause problems.  This is equivalent to 50 g licorice sweets. However, in most people, they can consume up to 400 mg before experiencing symptoms, which would be about 200 g licorice sweets. A rule of thumb says a normal healthy person can consume 10 mg GZA a day. 
In vitro , clotrimazole exhibits fungistatic and fungicidal activity against isolates of Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis, Candida spp. and Malassezia pachydermatis (Pityrosporum canis) . Resistance to clotrimazole is very rare among the fungi that cause superficial mycoses. In an induced otitis externa infected with Malassezia pachydermatis , 1% clotrimazole in the gentamicin-betamethasone-clotrimazole ointment vehicle was effective both microbiologically and clinically in terms of reduction of exudate odor and swelling.
Hypercortisolism can occur in several disorders other than Cushing's syndrome [ 1,2 ]. When such patients present with clinical features consistent with Cushing's syndrome, they may also be referred to as having physiologic hypercortisolism or pseudo-Cushing's syndrome. Clinically, patients with these physiologic forms of hypercortisolism seldom have the cutaneous (ie, easy bruising, thinning, and friability) or muscle (ie, proximal muscle atrophy and weakness) signs of Cushing's syndrome [ 3 ]. However, these conditions/disorders should be excluded when evaluating patients for Cushing's syndrome. (See "Establishing the diagnosis of Cushing's syndrome", section on 'Exclude physiologic hypercortisolism' .)