Potency topical steroids table

  1. Slideshow: Psoriasis Symptoms, Causes and Treatment
  2. Psoriasis Quiz: Test Your Medical IQ
  3. Moderate to Severe Forms of Psoriasis Slideshow
IN THIS ARTICLE
  • What Is Psoriasis?
  • What Are Psoriasis Causes and Risk Factors?
  • What Are Psoriasis Symptoms and Signs?
  • When Should People Seek Medical Care for Psoriasis and Its Associated Problems?
  • How Do Doctors Diagnose Psoriasis?
  • Are There Psoriasis Home Remedies?
  • What Are Psoriasis Treatment Options?
  • Are There Topical Medications for Psoriasis?
  • Systemic Medications for Psoriasis
  • Are There Other Therapies for Psoriasis?
  • Follow-up After Treatment of Psoriasis
  • Is There a Psoriasis Diet? Can People Prevent Psoriasis?
  • What Is the Prognosis of Psoriasis?
  • Psoriasis Support Groups and Counseling
  • Where Can People Find More Information About Psoriasis?
  • Psoriasis Pictures
  • Read more on Psoriasis from Healthwise
  • Psoriasis Topic Guide
Are There Topical Medications for Psoriasis?

Category C. Corticosteroids are generally teratogenic in laboratory animals when administered systemically at relatively low dosage levels. The more potent corticosteroids have been shown to be teratogenic after dermal application in laboratory animals. There are no adequate and well-controlled studies in pregnant women on teratogenic effects from topically applied corticosteroids. Therefore, topical corticosteroids should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Drugs of this class should not be used extensively on pregnant patients, in large amounts, or for prolonged periods of time.

Corticosteroids have been used as drug treatment for some time. Lewis Sarett of Merck & Co. was the first to synthesize cortisone, using a complicated 36-step process that started with deoxycholic acid, which was extracted from ox bile . [43] The low efficiency of converting deoxycholic acid into cortisone led to a cost of US $200 per gram. Russell Marker , at Syntex , discovered a much cheaper and more convenient starting material, diosgenin from wild Mexican yams . His conversion of diosgenin into progesterone by a four-step process now known as Marker degradation was an important step in mass production of all steroidal hormones, including cortisone and chemicals used in hormonal contraception . [44] In 1952, . Peterson and . Murray of Upjohn developed a process that used Rhizopus mold to oxidize progesterone into a compound that was readily converted to cortisone. [45] The ability to cheaply synthesize large quantities of cortisone from the diosgenin in yams resulted in a rapid drop in price to US $6 per gram, falling to $ per gram by 1980. Percy Julian's research also aided progress in the field. [46] The exact nature of cortisone's anti-inflammatory action remained a mystery for years after, however, until the leukocyte adhesion cascade and the role of phospholipase A2 in the production of prostaglandins and leukotrienes was fully understood in the early 1980s.

Potency topical steroids table

potency topical steroids table

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