Receptor sites for steroid hormones

Each column of the figure represents the responses of a single taste receptor to four different solutions, one from each submodality. The height of the bar indicates the magnitude of the response that particular receptor gave when the particular solution was poured over it. Looking at the response of only one receptor, it is impossible to tell what the stimulus was. For example, receptor 1 responds equally to salty and sweet and thus cannot distinguish between the two. By comparing the responses of the four cells, it is possible to detect which stimulus was presented. Salty corresponds to large discharges from receptors 1 and 3, sweet to large discharges from receptors 1 and 4, and so on. There is a unique pattern of discharge across the group of receptors for each different quality, even though no one receptor can signal a given quality uniquely; obviously, there are more than four taste receptors in the tongue, but a similar principle could be applied to a much larger set of receptors. Nonimpulse codes

Synthetic tetrahydrocannabinol (THC) is prescribed under the INN dronabinol or the brand name Marinol , to treat vomiting and for enhancement of appetite , mainly in people AIDS as well as for refractory nausea and vomiting in people undergoing chemotherapy . [33] THC is also an active ingredient in nabiximols , a specific extract of Cannabis that was approved as a botanical drug in the United Kingdom in 2010 as a mouth spray for people with multiple sclerosis to alleviate neuropathic pain , spasticity , overactive bladder , and other symptoms. [34]

More recently, androgen receptors have been shown to have a second mode of action. As has been also found for other steroid hormone receptors such as estrogen receptors , androgen receptors can have actions that are independent of their interactions with DNA. [13] [29] Androgen receptors interact with certain signal transduction proteins in the cytoplasm. Androgen binding to cytoplasmic androgen receptors can cause rapid changes in cell function independent of changes in gene transcription, such as changes in ion transport . Regulation of signal transduction pathways by cytoplasmic androgen receptors can indirectly lead to changes in gene transcription, for example, by leading to phosphorylation of other transcription factors.

Receptor sites for steroid hormones

receptor sites for steroid hormones

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